Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.

The effectiveness ratings for DHEA are as follows:

Likely effective for…

• Thinning of vaginal tissue (vaginal atrophy). Using vaginal inserts containing DHEA can reduce pain during sex by up to 15% after menopause. A prescription DHEA product is available for this condition.

Possibly effective for…

• Aging skin. Taking DHEA by mouth or applying it to the skin might improve skin appearance after menopause and in people over the age of 60 years.
• Depression. Taking 30-500 mg of DHEA by mouth daily seems to improve symptoms of depression. Lower doses don’t seem to help.
• Inability to become pregnant within a year of trying to conceive (infertility). Taking DHEA by mouth before in-vitro fertilization (IVF) might improve the chances of pregnancy and having a baby. But it’s not clear if taking DHEA helps prevent miscarriage after IVF.

Possibly ineffective for…

• Aging. Taking DHEA by mouth daily for up to 2 years doesn’t seem to improve body shape, bone strength, muscle strength, or quality of life in people older than 60 who have low DHEA levels.
• Muscle strength. Taking DHEA by mouth doesn’t improve muscle strength in adults.
• Physical performance in elderly adults. Taking DHEA by mouth doesn’t improve physical performance in older adults.

Likely ineffective for…

• Memory and thinking skills (cognitive function). Taking DHEA by mouth does not seem to improve mental function or decrease mental decline in healthy older people, people with HIV, or in healthy young adults.
• An autoimmune disorder in which the glands that produce tears and saliva are damaged (Sjogren syndrome). Taking DHEA by mouth does not improve symptoms of this condition.

There is interest in using DHEA for a number of other purposes, but there isn’t enough reliable information to say whether it might be helpful.

When taken by mouth: DHEA is possibly safe when used short-term. DHEA has been used safely for up to 2 years, usually in doses of 50 mg daily. DHEA side effects are usually mild and might include acne and upset stomach.

DHEA is possibly unsafe when used in high doses or long-term. Do not use DHEA in doses higher than 50-100 mg daily or for a long period of time. Using higher doses or using it long-term can increase the risk of serious side effects including cancer.

When applied to the skin: DHEA is possibly safe when used appropriately. DHEA cream has been used safely for up to 1 year.

When applied into the vagina: DHEA is possibly safe when used appropriately. DHEA vaginal inserts have been safely used for up to 3 months.

Special precautions & warnings:

Pregnancy and breast-feeding: DHEA is possibly unsafe when taken during pregnancy or breast-feeding. It can cause higher than normal levels of a male hormone called androgen. This might be harmful to the baby. Do not use DHEA if you are pregnant or breast-feeding.

Diabetes: DHEA can affect how insulin works in the body. If you have diabetes, monitor your blood sugar carefully if you are taking DHEA.

Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: DHEA is a hormone that can affect how estrogen works in the body. If you have any condition that might be made worse by estrogen, do not use DHEA.

High cholesterol: DHEA might lower high-density lipoprotein (HDL or “good”) cholesterol, especially in females. If you have high cholesterol or heart disease, talk with your healthcare provider before taking DHEA.

Liver problems: DHEA might make liver problems worse. Do not use DHEA if you have liver problems.

Depression and mood disorders: DHEA might cause excitability, impulsiveness, and irritability in people with mood disorders. If you have a mood disorder, talk to your healthcare provider before taking DHEA.

Polycystic ovary syndrome (PCOS): Taking DHEA might make this condition worse. Don’t use DHEA if you have PCOS.

Moderate

Be cautious with this combination.

Fulvestrant (Faslodex)

Estrogen-sensitive cancers are cancers that are affected by estrogen levels in the body. Fulvestrant is used for these types of cancer. DHEA might increase estrogen in the body and decrease the effects of fulvestrant for treating cancer. Do not take DHEA if you are taking fulvestrant.

Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)

Some medications are changed and broken down by the liver. DHEA might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

Medications for depression (Antidepressant drugs)

There is some concern that taking DHEA along with antidepressant drugs might increase the risk for serious side effects. Speak with a healthcare provider before taking DHEA if you are taking an antidepressant.

Medications for estrogen sensitive cancers (Aromatase inhibitors)

The body changes DHEA to estrogen in the body. Aromatase inhibitors are used to help lower estrogen levels in the body. Taking DHEA might decrease the effects of aromatase inhibitors.

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)

DHEA might slow blood clotting. Taking DHEA along with medications that also slow blood clotting might increase the risk of bruising and bleeding.

Tamoxifen (Nolvadex)

Estrogen-sensitive cancers are cancers that are affected by estrogen levels in the body. Tamoxifen is used to help treat and prevent these types of cancer. DHEA increases estrogen levels in the body and might decrease the effects of tamoxifen. Do not take DHEA if you are taking tamoxifen.

Triazolam (Halcion)

DHEA might decrease how quickly the body breaks down triazolam. Taking DHEA with triazolam might increase the effects and side effects of triazolam.

Tuberculosis Vaccine

Taking DHEA might reduce the effects of the tuberculosis vaccine. Do not take DHEA if you are receiving a tuberculosis vaccine.

Minor

Be watchful with this combination.

Estrogens

DHEA might increase estrogen levels in the body. Taking DHEA along with estrogen might cause too much estrogen in the body.

Testosterone

Taking DHEA with testosterone might cause there to be too much testosterone in the body. This might increase the effects and side effects of testosterone.

Herbs and supplements that might slow blood clotting

DHEA might slow blood clotting and increase the risk of bleeding. Taking it with other supplements with similar effects might increase the risk of bleeding in some people. Examples of supplements with this effect include garlic, ginger, ginkgo, nattokinase, and Panax ginseng.

Licorice

Taking licorice increases levels of DHEA in the body. Taking licorice with DHEA might increase the side effects of DHEA.

Soy

It was previously thought that soy might decrease the effects of DHEA, but this doesn’t seem to be a major concern.

It was previously thought that eating soy or a high fiber diet might decrease the effects of DHEA, but this doesn’t seem to be a major concern.

DHEA has most often been used by adults at a dose of 50 mg by mouth daily for up to 1 year. DHEA is also available in topical creams and vaginal products. Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition.